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You are here: Home / Uncategorized / How to Cure Hypothyroidism and Anxiety

How to Cure Hypothyroidism and Anxiety

January 24, 2020 by Dr. Gil Winkelman 19 Comments

In medicine, hypothyroidism and anxiety aren’t typically associated. It is usually depression associated with a low thyroid function and anxiety with high. But many of my patients found their anxiety disappear with proper thyroid function. Why is this? Could low thyroid be the answer to treatment-resistant anxiety? Many patients come to me taking thyroid but are not feeling better. Others presented with subclinical hypothyroid. Why is this? Let’s explore more about these issues. I should note that hormone interactions in the body are very complex. This article does not serve as a full primer but a short introduction.

Before jumping into the complexity of hormones, I want to review the scope of the problem. Anxiety occurs in 30-40% of patients with hypothyroid. They can also have irritability, depression, learning issues, and poor concentration.

The Causes of Hypothyroidism (and Anxiety)

Most research suggests that doctors should not give medications for depression and anxiety until they check thyroid levels. While I agree with the approach in theory, it’s not as simple as testing thyroid.
To understand the paradox of this problem, I want to explain a bit about the hypothalamic-pituitary axis (HPT). This may be technical but bear with me. The hypothalamus and pituitary are in the brain, controlling hormonal function in the body through different hormones. The hypothalamus produces Thyrotropin-releasing hormone (TRH) to signal the pituitary to make thyroid-stimulating hormone (TSH). TSH signals to the thyroid to produce T4 (Thyroxine) which is stored in the thyroid gland until the body needs to use it. When the body needs energy, T4 converts to T3 (Triiodothyronine).

Because T3 is so potent, the body only converts what it needs when it needs it and mostly inside the cell. T3 then crosses into the nucleus and started turning genes on. If you have listened to my podcast about methylation and epigenetics, there may be a connection here. Remember that everything you eat, drink, breathe, and experience can change your genetic expression. Specifically, high or low methyl may affect T3 binding at specific sites, thereby producing different results. The following are  required for the thyroid to work:

  • Hypothalamic/pituitary function
  • Secretion of TSH
  • Thyroid function (secretion of T4)
  • Thyroid hormone transport into the cell
  • Conversion of T4 to T3
  • Receptor binding
  • Downstream activation

There are a lot of steps. I want you to remember this list because it will be important in a moment.
But the doctor said my thyroid levels were normal!
Both the tests for thyroid and their interpretation are problematic. Typically, most doctors only run a TSH to see if thyroid is functioning well. But many recent research studies suggest that TSH is a poor measure of thyroid function. Several studies concluded that looking at just TSH does not show how cells are utilizing thyroid.

Some doctors know this and also measure T4 to determine thyroid function. There are problems with this approach. First, both TSH and T4 measure supply of thyroid hormone. A normal TSH means that the pituitary receives the message from the hypothalamus to tell the thyroid to produce thyroid. When these numbers are normal, most likely, your  thyroid is working. But often in hypothyroidism, the problem stems from somewhere further downstream from the gland. Look at the list above. There are four more steps below the level of the thyroid that can lead to hypothyroidism.

More Problems with Thyroid Tests

If TSH or T4 is off, most clinicians give T4! That helps nothing further downstream, and it could make things worse for many people too. Why? Because the body may convert too much T4 to reverse T3. This blocks the receptor sites for good T3 but no cell activity changes. Reverse T3 also stops conversion of T4 to T3. When this occurs, treatment to reduce reverse T3 must be given before thyroid function can return to normal.
The other big problem with this testing is that it presupposes that if there’s T4 that the T4 is getting into the cell and the body is converting it all to T3. But that is not always the case.

But my doctor tested the T3 and it was normal!
I’ve done that too but what we are finding that measuring T3 and T4 are not always good indicators of thyroid function either. One problem is that T3 is an intracellular component meaning that we don’t see a lot in the blood. Therefore, doing a blood test tells us nothing about how the cell is utilizing T3.

But the biggest problem with these tests is that many common conditions skew the results. For example, patients with fibromyalgia have low normal TSH normal T4 but low T3. Doctors typically treat these patients as though their thyroid is either normal or on the high end. Patients who are obese typically have thyroid results that do not correlate with their symptoms. The same is true of patients with high levels of inflammation and diabetes.

Many conditions may be issues of conversion of T4 to T3. Why is this happening? Much of the research suggests that chemicals such as flame retardants, bisphenol A, plastics, heavy metals and such. These compounds may disrupt the energy production mechanisms in cells called mitochondria.

Why am I Anxious if I’m Hypothyroid?

You may wonder how this related to anxiety. The short answer is we don’t know. My best guess is that the sympathetic nervous system kicks in to speed up processes in the body. Adrenaline rushes over long periods leads to anxiety.

If you suffer from anxiety, depression, learning issues, or brain fog, it’s time to get your thyroid checked. There are better ways to test thyroid than just doing a TSH including taking your temperature or measuring other hormone in the body such as sex hormone binding globulin. This is what I do in my practice now instead of measuring just the thyroid levels.  I am certified in Wilson’s Temperature Syndrome therapy, a novel approach to correct issues with thyroid conversion. In  fact many people who were previously diagnosed with Hashimoto’s or other thyroid issues, regained healthy thyroid function after  this  treatment  approach. Schedule  with me if you want to learn  more.  Your path to feeling better is just around the corner.

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Comments

  1. Margaret Whitetree says

    November 30, 2020 at 7:23 AM

    I wonder if the Wilson’s syndrome treatment is appropriate for somebody who’s been diagnosed with Hashimoto’s?

    Reply
    • Dr. Gil Winkelman says

      August 23, 2024 at 1:24 PM

      Wilson’s Syndrome Treatment has definitely helped hashimoto’s patients. Often the Hashimoto is misdiagnosed.

      Reply
  2. Natalie Edwards says

    November 15, 2021 at 8:29 PM

    Genius! You are the only one I have read to make sense in 20 years.

    I am mthfr-c677t
    Hypothyroid-ADHD-Impulsivity-anxiety

    No one gets it and I would love to see you via telemed if at all possible.

    Reply
    • Dr. Gil Winkelman says

      February 24, 2022 at 4:23 PM

      Thank you! Please call the office when you get a chance to schedule.

      Reply
  3. Diane lumley says

    June 29, 2022 at 9:49 AM

    I have hypothyroidism and doc says it’s underactive but borderline I suffer from bad anxiety all the time and my thyroid hurts on the right side , I’m having more bloods done and have a different doc so I’m hoping he can help me

    Reply
  4. Roe says

    October 11, 2022 at 8:50 AM

    Hi,

    I have found over the years that the thyroid is a sensitive subject to talk about with your doctor. Asking for alternatives is forbidden.

    I didn’t ‘suddenly’ have thyroid problems until I was visiting a fertility doctor, not because I couldn’t conceive but to have my eggs frozen for the future.
    I have been taking medication for my thyroid for five years now.

    I had recently went in for a annual thyroid check this year, but did not know I was positive for Covid at the time. They ran the test for my thyroid and said it was ‘out of whack’ literally. So my doctor said let’s increase your dosage from 25mg to 50mg. I did as told and hours later I went into a severe panic attack and felt like I was drugged. Let me just say “I don’t get panic or anxiety attacks in the first place”, this was something new.

    I called my doctor that Monday to let him know I was positive for Covid at the time my blood was drawn for the thyroid test..along with the list of symptoms I experienced after the dosage increase. The only response I received was ‘keep taking the 50mg and we’ll see you in a couple months.
    Not the response I expected but than again…the test results is the only thing that matters, right.

    Thank you for at least informing people and trying to help & listen to your patients instead of ‘just’ what the manual says!

    Reply
  5. Sharon Rose says

    October 14, 2022 at 9:28 AM

    Hello Dr. Gil,
    I like this article, sounds right on. I asked drs. To put me on armour thyroid, thinking it might be better, but they don’t.
    I was put on progesterone, bioidentical, but not sure if it’s good for me or needed.

    Thanks alot,
    Sharon

    Reply
  6. Mary says

    January 5, 2023 at 10:52 AM

    This is such a comprehensive article on thyroid issues. Explains why so many of us thyroid patients suffer so many symptoms despite having normal test levels.

    Reply
    • Dr. Gil Winkelman says

      April 4, 2023 at 5:49 PM

      Thank you!

      Reply
  7. Mary says

    January 31, 2023 at 3:14 AM

    Hello,

    How can I contact you to know more?

    Reply
    • Dr. Gil Winkelman says

      April 4, 2023 at 5:46 PM

      Apologies for the delay. Please call or email the office. 503-894-7437

      Reply
  8. Cynthia says

    February 6, 2023 at 10:16 PM

    Hashimotos/severe anxiety

    Reply
  9. Rye Saavedra says

    June 28, 2023 at 1:59 AM

    Dear Dr. Gil, thank you for sharing your insightful article about the cure for hypothyroidism and anxiety. Your willingness to shed light on such an important topic is truly empowering and inspiring. Your words provide comfort and guidance to those who may be struggling with the illness, and your expertise in the field is greatly appreciated. Your article is a reminder that we are not alone in our struggles, and that there is hope for healing. Your contribution to the mental health community is invaluable and I hope to see more of your work in the future. Thank you again for sharing your wisdom and helping us all on our journey toward better mental health.

    Reply
  10. Holly Glenn says

    July 10, 2023 at 2:23 PM

    Vaccine threw my TSH from 3.14 to 15.8 in 18 days. Have been debilitatingly sick since the vaccine. Been taking 30 mg NP for 15 months and recently switched to Armor, wondering it NP was causing the anxiety and Hyperacusis. No change. But when I forget to take my thyroid medication, I feel better. Any experience with covid vaccine injuries?

    Reply
    • Dr. Gil Winkelman says

      August 22, 2023 at 12:59 PM

      Some, though I suspect based on treating people with long Covid. They have similar issues as a result so it may be less to do with the vaccine and more to do with the way the body responds to the virus.

      Reply
  11. Diane Lindberg says

    December 18, 2023 at 11:35 AM

    Please help me with my hashmoto and severe anxiety!Doctors won’t help! Every time take thyroid medicine I get deathly sick!!!

    Reply
    • Dr. Gil Winkelman says

      December 21, 2023 at 8:36 AM

      Hi Diane,

      I’m sorry to hear you’re struggling. I would suggest calling the office to discuss. 503-894-7437

      Reply
  12. Sue Ferreira says

    April 9, 2024 at 9:48 AM

    Hi , I’ve had hypothyroidism for years. (Taking Levothyroxine) Also on steroid replacement therapy due to adrenal glands being removed in 2006. My anxiety and depression have reached extreme levels and I don’t know what to do.

    Reply
    • Dr. Gil Winkelman says

      June 9, 2024 at 6:56 PM

      Most likely you need to work with someone to balance both adrenal and thyroid.

      Reply

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